Physiological Engineering Aspects of Pen

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The book gives a review of penicillin production by Penicillium chrysogenum, and also deals with a number of general aspects of fungal cultivations, e.g. primary metabolism of filamentous fungi, morphology, monitoring of fungal cultivations, and bio…

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    Om Physiological Engineering Aspects of Pen

    The book gives a review of penicillin production by Penicillium chrysogenum, and also deals with a number of general aspects of fungal cultivations, e.g. primary metabolism of filamentous fungi, morphology, monitoring of fungal cultivations, and bioreactor performance (more than 750 references).The first two chapters give an introduction to the area of penicillin production; with a review of the history and a survey of the present status of this industrially very important process in the first chapter. In the second chapter is given an introduction to the microorganism, i.e. its nutritional requirements, its taxonomy, and an overview of different strain development programmes.Chapter 3 gives an introduction to the concept of Physiological Engineering. This is followed by a review of various monitoring techniques and different theoretical techniques for analysis of cultivation processes, e. g. mathematic modeling, metabolic flux analysis, and metabolic control analysis.Chapter 4 and 5 give a review of the metabolism, with the primary metabolism being the topic of Chapter 4 and the secondary metabolism, i.e. penicillin biosynthesis, being the topic of Chapter 5. The review of the penicillin biosynthetic pathway is followed by a description of a number of results obtained using metabolic flux and metabolic control analysis.Chapter 6 is devoted to the morphology of the fungus, and it gives a detailed description of the growth mechanisms of filamentous fungi.Chapter 7 deals with the bioreactor performance during fungal cultivations, i.e. medium rheology, gas-liquid mass transfer, and mixing.Finally is the fed-batch process applied for penicillin production described in Chapter 8. It gives an overview of the most important factors influencing penicillin production.Contents: History and Present Status of Penicillin ProductionThe MicroorganismPhysiological EngineeringPrimary MetabolismPenicillin BiosynthesisMorphology in Submerged CulturesBioreactor PerformancePenicillin Production in Fed-Batch CulturesReadership: Students and researchers in microbiology, biotechnology, biology and industrialists.Key Features:Interesting selection of topics, from particle physics to quantum information to condensed matter to nuclear disarmamentRenowned contributorsMany innovative ideas explored

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    Detaljer

    Format
    E-Bok
    Filformat
    PDF
    Utgivelsesår
    1997
    Forlag
    World Scientific Publishing Co
    Språk
    Engelsk
    ISBN
    9789812819987
    Sider
    288

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