This book describes principles, industry practices and evolutionary methodologies for advanced safety studies, which are helpful in effectively managing volatile, uncertain, complex, and ambiguous (VUCA) environments within the framework of quantitative risk assessment and management and associated with the safety and resilience of structures and infrastructures with tolerance against various types of extreme conditions and accidents such as fires, explosions, collisions and grounding. It presents advanced computational models for characterizing structural actions and their effects in extreme and accidental conditions, which are highly nonlinear and non-Gaussian in association with multiple physical processes, multiple scales, and multiple criteria. Probabilistic scenario selection practices and applications are presented. Engineering practices for structural crashworthiness analysis in extreme conditions and accidents are described. Multidisciplinary approaches involving advanced computational models and large-scale physical model testing are emphasized. The book will be useful to students at a post-graduate level as well as researchers and practicing engineers.