This book examines how Artificial Intelligence is transforming ethics, creativity, and responsibility in digital transformation and what this means for the future of innovation. Building on the previous two volumes, Leadership for Digital Transformation: Navigating the Journey and Digital Transformation in Knowledge Transfer: Shaping the Future, it explores how human values can guide human-centered technological progress across business, education, and society. Drawing on the practical experience of the Institute for Digital Transformation and Innovation (IDTI) at BSP Business and Law School, the book connects research with application. It offers frameworks and real-world examples for responsible AI, ethical governance, and sustainable innovation, with a focus on SMEs. Distinctive for its action-oriented approach, the volume moves ethics from theory to practice. Through interdisciplinary and international perspectives, it addresses algorithmic bias, AI literacy, sustainability, and digital democracy, showing how technology can serve humanity. Contributions from experts across Europe, Latin America, and beyond provide globally relevant insights and practical solutions for fostering responsibility in an AI-driven world.