At the center of the 2,000 mile U.S.-Mexico border, a sprawling transnational urban space has mushroomed into a metropolitan region with over two million people whose livelihoods depend on global manufacturing, cross-border trade, and border control jobs. Our volume advances knowledge on urban space, gender, education, security, and work, focusing on Ciudad Juárez, the export-processing (maquiladora) manufacturing capital of the Americas and the infamous site of femicide and outlier murder rates connected with arms and drug trafficking. Given global economic trends, this transnational urban region is a likely paradigmatic future for other world regions.