Set in Tanga, a city on the Tanzanian Swahili coast, Dominik Mattes examines the implementation of antiretroviral HIV-treatment (ART) in the area, exploring the manifold infrastructural and social fragilities of treatment provision in public HIV clinics as well as patients’ multi-layered struggles of coming to terms with ART in their everyday lives. Based on extensive ethnographic fieldwork, the book shows that, notwithstanding the massive rollout of ART, providing treatment and living a life with HIV in settings like Tanga continue to entail social, economic, and moral challenges and long-term uncertainties, which contradict the global rhetoric of the “normalization of HIV”.