The texts in these four volumes deal with the history and philosophy of mathematics and its applications. The first three volumes are devoted to the history of mathematics (arithmetic, algebra, geometry), optics and astronomy, from Antiquity to the Classical Age. Over the last fifty years, the numerous studies contained in this volume have renewed the study of the main Greek mathematicians - Euclid, Archimedes, Apollonius, Diophantus, Menelaus - and have shown the nature and scope of their reception and transformations, both in classical Islam and in early European modernity. The fourth volume establishes and explores various fields of research between philosophy and mathematics, from the polymorphous interactions specific to Greek, Arab and Latin science to the mathematisation of the social sciences in the eighteenth century. Both in terms of the novelty of the material discovered and published for the first time and the power and finesse that continue to guide its epistemological analysis, the dozens of contributions collected here represent a major work that has changed the history of science in our time.