This volume brings together a collection of essays from researchers engaged in, or concerned with, the politics of global health. It addresses the power relations which drive global health strategies, frustrate the possibility of effective engagement and operate to relegate billions of people to a vulnerable and bleak future. From a broad engagement with the global health system, the volume focuses on arguably the most pressing public health issue of modern times - the effective global governance of HIV/AIDS. The underlying objective is to help generate a timely debate and understanding of the impact of globalization on health and the plight of the vulnerable.