Product Lifecycle Management (PLM) manages a product’s journey from concept through service and end-of-life, supporting circular economy practices by centralizing information and aligning business processes. It drives business strategy by enabling innovation, improving efficiency, and ensuring quality, helping manufacturers deliver smart, sustainable products in the age of Industry 4.0 through Industry 5.0. This handbook provides complete coverage of PLM, what manufacturing enterprises are trying to accomplish on a strategic level, and how it can best be leveraged to help kick-start their digital transformation journey. Structured in five parts, the Handbook of Product Lifecycle Management (PLM): Fundamentals, Components, and Implementation Best Practices guides readers from PLM foundations and digital strategy to implementation, value realization, and the emerging concept of PLM 5.0. It connects principles with practice through frameworks, examples, and real-world business scenarios, simplifying complex ideas for both technical and nontechnical audiences. Covering key pillars of manufacturing and emerging technologies in Industry 4.0 and Industry 5.0, it positions PLM as a strategic, people-centric business initiative. This handbook is a one-stop guide for professionals who must perform a seamless PLM implementation for the manufacturing sector. Small-, medium-, and large-size enterprises across the globe irrespective of the PLM Platform will find this handbook an excellent guide. Academics will consider this handbook an eye-opener in choosing their career, and it will be an asset to them when setting up the Center of Excellence for practical learning.