Examining popular media portrayals of various health topics, this book offers a critical analysis of how those mediated messages can impact, for good or ill, people’s physical and mental health. Looking specifically at how various depictions of health topics have both aided in the normalization of health topics such as neurodiversity and HIV while also critiquing the dissemination of misinformation on these same topics, this book offers insight into the ways in which humorous content can both help and hurt. The author draws on a critical analysis of popular media including shows, social media, and stand-up specials, as well as interviews with those who use humor within health settings, such as Red Nose Docs, comedians who focus on their own health issues. This insightful study will interest scholars and students of health in popular culture as well as health communication, media studies, public health administration, and health policy.