This book deals with the complexity of art by focusing on the singularity of the work of art. Gathering a selection of writings in art theory and semiotics, it explores the question of apprehending art from its perceptual aspects to aesthetic comprehension and understanding. Theoretical enquiries focus in particular on the dynamics of the perception of forms, the semiotic value of colour, the aesthetic phenomenon of empathy, the function of vision in relation to other senses and its faculty to lead, in a substantial way, to the embodiment of sense. These theoretical points are constantly observed with reference to the analysis of works of art, especially from the beginning of the modern era, when a renovated psychophysical approach oriented the evolution of contemporary aesthetics. Research into art theories sheds light on how differentials in topologic positions, dimensions, relationships and tones contribute to the arising of forms and colours in perception, and affect the perceiver. The essays presented address in different ways the emergence of sense, by conceiving it as deeply anchored to the dynamics of perception, in addition to the cognitive disposition and knowledge, regardless of whether or not the subject (artist or beholder) is aware of these processes. Through in-depth analyses identifying to what extent the aesthetic moment builds on perceptual and semiotic processes, works of art are revealed to be singularities, reflecting the correlation with morphodynamics in the sciences.