In the era of big data and real-time monitoring, vast amounts of information are generated every second through sensors and advanced tracking systems. The information contained in the data needs to be carefully analyzed and accurate results must be delivered to the users as soon as possible. This book explores the critical role of statistics in modern technologies and applied sciences such as health, informatics, and production systems. Statistical Methods and Applications in Systems Assurance and Quality provides a comprehensive overview of statistical methods for ensuring system quality and reliability. It discusses best practices for improving the quality of manufacturing products by using proper statistical methods. The book covers the current state of statistical methods used for system quality and conveys the importance of healthcare systems and employing statistics in the detection of epidemic outbreaks. Designed for researchers, industry professionals, and academics, this reference is ideal for those working in manufacturing, healthcare, computer engineering, statistical process control, and machine learning applications. It serves as a valuable resource for anyone seeking to enhance system performance through data-driven insights.