It seems clear that many formerly stable societies in wealthy developed countries appear to be falling into an apparent state of ‘permacrisis' accompanied by an increasingly angry and irrational social and political culture that is undermining the peace and stability of our societies and democratic institutions, from the local to the global. Applying an original biosocial approach (the social map), and drawing on ideas and evidence from sociology, history and political economy, to psychology, neuroscience and epigenetics, John Bone argues that conditions in our turbocapitalist and increasingly estranged, media dominated societies have created a toxic environment, deeply damaging to our mental and physical health. As well as shedding new light on our current troubles, Bone also outlines why this leaves us ill prepared to deal with two of the greatest challenges confronting humanity: the rise of AI and automation and how we deal with climate change.