This handbook provides fresh insights into the debates and challenges that unfold in the cross-disciplinary field of architecture and anthropology. Based on studies of empirical contexts across the globe, the authors launch and test a broad variety of methods and advance various theoretical concepts. Architecture and anthropology have always had overlapping interests, but a range of developments in both areas make it more relevant than ever to intersect, overlap, combine or even merge the two disciplines. In anthropology, the spatial, material, and nonhuman turns have paved the way for an increasing interest in, and need for, of changing the world, rather than just studying it. On the other hand, architecture, beyond designing structures, has become interested in the uses and processes that unfold in, during, and after construction. The contemporary research and practices in both disciplines are testimonies that a cross-disciplinary exchange is inspiring for engaging with, and responding to, the challenges of a world in ecological, societal, and political turmoil. This handbook addresses established scholars, students, and practitioners alike by outlining contemporary developments and tensions at the intersection of architecture and anthropology.