Is mental illness – or madness – at root an illness of the body, a disease of the mind, or a sickness of the soul? Should those who suffer from it be secluded from society or integrated more fully into it? This Way Madness Lies explores the meaning of mental illness through the successive incarnations of the institution that defined it: the madhouse, designed to segregate its inmates from society; the lunatic asylum, which intended to restore the reason of sufferers by humane treatment; and the mental hospital, which reduced their conditions to diseases of the brain. Moving and sometimes provocative illustrations and photographs, sourced from the Wellcome Collection's extensive archives and the archives of mental institutions in Europe and the U.S., illuminate and reinforce the compelling narrative, while extensive ‘gallery’ sections present revealing and thought-provoking artworks by asylum patients and other artists from each era of the institution and beyond.