In this issue of Clinics in Perinatology, guest editors Drs. G. Ganesh Konduri and Satyan Lakshminrusimha bring their considerable expertise to the topic of Advances in Respiratory Care of the Newborn. Top experts provide valuable insights into reducing the burden of respiratory morbidity and mortality in neonates, ultimately improving survival and quality of life for the most vulnerable patients. This issue covers cutting-edge advances, management of complex conditions, and today’s innovative therapies. Contains 14 practice-oriented topics, including recent advances in the extra-corporeal life support of neonates for cardiopulmonary failure; home oxygen use and post-discharge management of infants with bronchopulmonary dysplasia; evaluation and management of genetic respiratory disorders presenting as hypoxic respiratory failure in the newborn; ex-utero artificial placental support: promising future for extremely preterm infants; and moreProvides in-depth clinical reviews of advances in respiratory care of the newborn, offering actionable insights for clinical practicePresents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews