With nearly 20% of the U.S. population identifying as Latina/o/x/e, Hispanic, or of Spanish Origin+ (LHS+) and this sub-population exhibiting unique health issues and disparities, there is a need for medical schools and academic health centers to hire and cultivate leaders with a LHS+ informed lens. This open access book aims to support LHS+ identified medical students, residents, fellows, and faculty in seeking and advancing in academic medicine leadership positions.  The book serves as a resource for academic medicine community members who advise, coach, mentor, and/or sponsor LHS+ individuals. The 50+ distinguished chapter co-authors, the majority LHS+ identified, describe best practices and lived professional experiences to instruct readers on how LHS+ identified individuals can succeed along faculty, senior medical school administrative, and/or academic hospital leadership ranks. The book provides data, evidence-based practices, reflection and skill building exercises, and narratives to engage readers.