This book presents technical advancements of artificial intelligence (AI)–based technologies and computational biology approaches, highlighting their applications in developing smart healthcare and precision medicine for managing infectious diseases. It discusses cutting-edge AI tools, particularly machine and deep learning models, and generative AI to assist in disease prediction and prevention, disease surveillance and diagnosis, drug discovery, drug design and development, healthcare, personalized medicine, pharmacology, and vaccine development. The contents fit the goal of establishing "Good Health and Well-Being," which is one of the "Sustainable Development Goals (SDGs) 2030."Key Features:• Includes AI/omics approaches in precision medicine and smart healthcare• Summarizes AI-driven drug and vaccine developments and AI tools for infectious disease prevention for clinicians, researchers, and policymakers• Proposes AI-based strategies for disease prediction, surveillance, and diagnosis