The book is covering knowledge and results in theory, methodology, and applications of artificial intelligence and machine learning in academia and industry. Nowadays, artificial intelligence has been used in every company where intelligence elements are embedded inside sensors, devices, machines, computers and networks. The chapters in this book integrated approach toward global exchange of information on technological advances, scientific innovations, and the effectiveness of various regulatory programs toward AI application in medicine, biology, chemistry, financial, games, law, and engineering. Readers can find AI application in industrial workplace safety, manufacturing systems, medical imaging, biomedical engineering application, different computational paradigm, COVID-19, liver tracking, drug delivery system, and cost-effectiveness analysis. Real examples from academia and industry give beyond state of the art for application of AI and ML in different areas. These chapters are extended papers from the First Serbian International Conference on Applied Artificial Intelligence (SICAAI), which was held in Kragujevac, Serbia, on May 19–20, 2022.