This book focuses on the systemic scientific-methodological and practical exploration of organizational-technical and socio-economic issues related to the automation of decision-making in the smart economy under Industry 4.0 using big data and artificial intelligence (AI). The scientific novelty of the results presented in the book lies in uncovering the “black box” of decision-making automation in the smart economy through these technologies. The book clarifies the role and significance of big data and AI in decision-making within the smart economy, highlighting its fundamental importance. Additionally, the book thoroughly discusses international experiences in decision-making automation in the smart economy, with examples from Armenia, Kyrgyzstan, and other Central Asian countries, demonstrating its empirical value. The book reveals advanced organizational-economic models for decision-making based on big data and AI. It also presents the latest trends in the development of the smart economy using big data and AI. Moreover, the book explains the socio-ecological and legal aspects of the ethics in applying big data and AI technologies. Additionally, the book proposes prospective applied solutions for decision-making in the smart economy based on big data and AI. The target audience of the book includes scientists studying big data and AI.