The “Cancer Immunotherapy and Nanobiotechnology: An Interdisciplinary Approach” is the twenty fifth volume of the “Interdisciplinary Cancer Research” series, publishes comprehensive volume on cancer immunotherapy and nanobiotechnology. The volume starts with chapters on targeting mitochondria in cancer immunotherapy, immunotherapy in oncology, and cancer treatments through immunological pathways. Immune checkpoint inhibitors as well as engineered iPSC-based strategies are explained in other chapters after discussion on cancer stem cells. CAR NK, CAR T cells, and DC therapy are the subjects of the following chapters. Then tumor microenviroment in response to immunotherapy and T-cell responses during cancer immunotherapy through the use of imaging are explained. The second half of the volume is focused on application of nanobiotechnology in cancer, starting with general chapters on nanotechnology for cancer research, nanotechnology and cancer therapy strategies, nanomedicine based cancer immunotherapy, applications of nanocarrier systems in cancer treatment, and nanoformulations in cancer theranostics. Then the role of metal nanomaterials in cancer therapy, synthetic drug nanodelivery systems, nanoparticles loaded with cytotoxic agents, nanocarrier-mediated drug delivery, vesicular nanosystem, and nanoscale metal-organic frameworks for cancer-targeted therapy are explained. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for those who wish to have an update on cancer immunotherapy and nanobiotechnology.