Chemical genomics technology has been steadily improving, delivering new biological probes and drugs, and the explicit use of the term ‘chemical proteomics’ has increased with it, as proteins have always been at the heart of this technology.  In Chemical Genomics and Proteomics: Reviews and Protocols, experts in the field present updated reviews of the chemistry of small molecules and their interaction with protein targets as well as detailed protocols that cover different types of ligands, carbohydrates, and lipids.  For example, the generation of their protein targets and methods for measuring their interactions is covered.  Written in the highly successful Methods in Molecular Biology™ series format, methodology chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  Thorough and up to date,  Chemical Genomics and Proteomics: Reviews and Protocols aims to provide inspiration to those who wish to use chemical genomics and proteomics in their work and develop this young field into full maturity through the incorporation of the new biological and chemical technologies beginning to emerge here.