This book gathers a selection of the articles accepted for presentation and discussion at the 2nd International Conference on Smart Learning Ecosystems and Regional Developments (SLERD 2017), held 22–23 June What characterizes smart learning ecosystems? What is their role in city and regional development and innovation? How can we promote the engagement of citizens in smart learning ecosystems? These are some of the questions addressed at SLERD 2017 and documented here. The proceedings include scientific papers that endeavor to understand, devise and promote innovative human-centric design and development methods, education/training practices, informal social learning, and citizen-driven policies. The individual papers elaborate on the notion of smart learning ecosystems, study the relation of smart learning ecosystems with As such, they help to foster the social innovation sectors, Information and Communication Technology (ICT) and economic development and deployment strategies, alongside new policies for smarter, proactive citizens – making them a valuable resource for researchers and policymakers alike.