With almost a third of the world's population living in South and Southeast Asia, these regions are particularly vulnerable to climate catastrophes such as rising sea levels, harsh weather, and changing disease patterns. They have impacted the regions to achieve the Sustainable Development Goals (SDGs), particularly Goal 3 (Good Health and Well-Being) and Goal 13 (Climate Action), which also put a burden on healthcare systems, especially among vulnerable populations. This book explores the impact of climate change on both physical and mental health, healthcare infrastructure, and practices in these vulnerable regions, proposing strategies for resilience and preparedness. In addition, the volume offers case studies and state-of-the-art research, providing insights into the infrastructure problems and health hazards associated with climate change. The book begins with an examination of the health effects of climate change, including heatwaves, poor air quality, vector-borne diseases, psychological impacts and nutritional insecurities. The second section focuses on healthcare systems, climate-resilient facilities, supply chain adjustments, and the role of telemedicine and climate-focused public health surveillance. The final section evaluates policy responses, community resilience, and international cooperation, including financial mechanisms to support climate-resilient health systems. The book is a valuable resource for policymakers, healthcare professionals, and researchers, and it provides evidence-based insights and practical recommendations to strengthen public health frameworks against the growing climate challenges in South and Southeast Asia.