Over the past several years, the world has faced a series of unprecedented challenges—public health crises, climate change, racial and socioeconomic tensions—that have intensified the ongoing epidemic of substance use and overdose. The Clinical Manual of Addiction Psychopharmacology, now in its third edition, asserts that substance misuse and addictive disorders, although complex in origin, are inherently treatable. This new edition is rich in information and practical guidance tailored to today's addiction psychiatry and addiction medicine workforce. The volume is organized by substance class—such as nicotine and tobacco, alcohol, cannabis, opioids, stimulants, and hallucinogens—offering quick access to essential information. Expert contributors synthesize the latest scientific advancements in how these substances affect those who misuse them, as well as the psychopharmacological and neurobiological bases for available treatments. This updated edition also features four new chapters: • Treatment of Substance Use Disorders: An examination of the pharmacotherapy of addictive disorders through a broader system-based and social lens• Behavioral Addictions: An exploration of emerging treatments for non-substance-related addictive disorders such as gambling disorder• Integrative Approaches to Addiction Treatment: A comprehensive review of treatment literature on nonstandard pharmacotherapies, including herbal supplements• Circuit-Based Interventions for Substance Use Disorders: A description of interventional approaches that include transcranial magnetic stimulation and deep brain stimulation Other chapters have been updated to reflect the changing social and clinical landscape in which clinicians practice. Additionally, epidemiological review has been intentionally minimized throughout the manual to allow readers to focus on the state of research and clinical treatment recommendations. The Clinical Manual of Addiction Psychopharmacology, Third Edition, is a foundational, accessible resource for all those who seek to support the clinical needs of their patients and communities.