This book explores the relevance of new sources, dimensions, and characteristics of knowledge for supporting creative and cultural organizations and initiatives. Special emphasis is placed on cultural heritage, participatory approaches, and entrepreneurship in the cultural and creative sector. The role of cultural heritage and contemporary culture as a source of economically effective, socially sustainable development is also discussed. The authors examine new ways of developing and testing new and innovative models of management for cultural heritage assets. In line with the participatory approaches in culture heritage governance promoted by the EU, the authors analyze participatory approaches to cultural and creative initiatives. The role of public and private actors, as well as the way they interact with each other in order to achieve collective outcomes, is of particular interest in this section of the book. With regard to cultural and creative entrepreneurship, the book adds an innovative view of cultural ventures, offering some clues from an entrepreneurial ecosystem perspective.