In today's data-driven business world, organizations struggle to extract actionable insights from vast amounts of information. This textbook bridges theory and practice, offering structured approaches to leverage data for enhanced decision-making through machine learning, AI, and optimization modeling—transforming raw data into competitive business intelligence. Decision Making and Analytics: Data-Driven Business Intelligence and Optimization features advanced analytical methodologies paired with real-world implementation studies, creating a progressive learning path from customer behavior analysis through hybrid decision models. By integrating fuzzy logic, neural networks, text mining, and reinforcement learning, it provides a comprehensive toolkit applicable across business scenarios, turning abstract concepts into practical solutions. Serving multiple audiences, this resource bridges the gap between classroom theory and industry practice for students in industrial engineering, business analytics, and management information systems. Practitioners gain applicable methodologies to improve organizational decision-making. At the same time, researchers benefit from cutting-edge approaches across various domains, and policymakers can develop data-informed strategies—addressing the growing demand for professionals who translate data into strategic decisions. The textbook employs open-ended questions that develop analytical reasoning skills without predetermined solutions, better preparing students for real-world complexity. Supporting materials include high-quality figure slides, as well as PowerPoint slides, for qualified adopters, enabling engaging learning environments that effectively communicate complex concepts while building practical, data-driven decision-making skills.