Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challenges. This book begins with a simple guide to understanding high blood sugar, tracing the historical milestones of hyperglycemia, and unveiling the primary factors that contribute to diabetes development, from genetic predisposition to lifestyle hazards. The second section aims to bridge the gap between diabetes and dementia, presenting early clinical evidence, case studies, and susceptibility assessments that underscore the strong link between hyperglycemia and neurodegeneration. Biomarkers and pathways connecting these conditions are explored, including the role of Advanced Glycated End (AGE) products and their implications in protein misfolding and aggregation. The narrative extends to therapeutic strategies, evaluating the efficacy of antidiabetic drugs, targeting insulin resistance, and introducing novel interventions to arrest amyloid-associated pathogenesis. This comprehensive guide provides both clinicians and researchers with a thorough understanding of the intricate link between diabetes and neurodegeneration.