This book constitutes the refereed proceedings of the 6th Multidisciplinary International Symposium on Disinformation in Open Online Media, MISDOOM 2024, held in Münster, Germany, during September 2–4, 2024. The 8 full papers presented in this book were carefully reviewed and selected from 15 submissions. The symposium tries to integrate the scientific process of multiple communities and offers a proceeding publication track as well as the submission of presentation proposals (as extended abstracts).