This book compiles the proceedings of the Second International Conference on Smart Computing and Communication for Sustainable Convergence (ISCCSC 2025). It brings together high-quality research, practical insights, and scholarly debate in the field of smart computing, artificial intelligence, machine learning, edge learning, data mining, image processing, smart communication, 5G/6G communication networks, signal processing, wireless sensor networks, antenna systems, imaging, and edge intelligence. This volume provides comprehensive coverage of emerging technologies, innovations, and trends shaping modern smart systems. It addresses real-world deployment challenges while presenting effective solutions, offering readers practical insights into communication paradigms essential for smart city ecosystems. Key focus areas include smart healthcare, smart transportation, and intelligent data processing, with detailed analysis of how advanced technologies enhance efficiency, safety, and decision-making. The integration of theoretical concepts with practical applications makes this an invaluable resource for researchers, academicians, industry professionals, and students exploring smart cities and next-generation communication systems.