Regenerative medicine is an emerging and integral part of interventional pain management and meets definitions of interventional pain management and interventional techniques. Interventional techniques are defined as minimally invasive procedures including, percutaneous precision needle placement, with placement of drugs in targeted areas or ablation of targeted nerves; and some surgical techniques such as laser or endoscopic diskectomy, intrathecal infusion pumps, and spinal cord stimulators, for the diagnosis and management of chronic, persistent, or intractable pain. On the same token, interventional pain management is defined as the discipline of medicine devoted to the diagnosis and treatment of pain related disorders principally with the application of interventional techniques in managing subacute, chronic, persistent, and intractable pain, independently or in conjunction with other modalities of treatment. This new edition brings a wide array of information for interventional pain physicians and other physicians practicing regenerative medicine with its applications in managing chronic pain and other disorders. The structure of the book begins with an introduction of the subject, followed by sections on historical context, pathophysiology, applicability of regenerative medicine with its evidence base, anatomy, technical aspects, complications, and precautions for each topic when available and applicable. From across the globe, leading experts in their respective fields contributed chapters on specific topics to present a cogent and integrative understanding of the field of regenerative medicine as applicable for interventional pain physicians. This comprehensive text achieves its goal of providing an evidence-based approach to application of principles of regenerative medicine in managing chronic pain of spinal, neurological, and musculoskeletal origins.