Frailty, a geriatric syndrome with a defined phenotype, was introduced by Linda Fried and Jeremy Walston; it is widely cited. The importance of this syndrome cannot be overstated: Frailty has an enormous relevance in clinical settings, and there are clear biological bases behind its phenotype. This book covers both biological and clinical aspects, including interactions with diseases like diabetes. Key Features: Summarizes the history and recognition of the Frailty Syndrome Provides an update and summary of a fast-growing field Describes how free radical and oxidative stress contributed to current theories Documents the impact that nutrition and physical activity play in the emergence of frailty