Hone your clinical reasoning and diagnostic skills with a new series of case-based topic-specific studies. This compilation of 20 gastroenterology-related cases includes presenting clinical manifestations and a discussion of the broad range of possible diagnoses, with a reveal of the actual diagnosis at the end. Cases cover gastrointestinal tumors, masses, and large cysts; primary gynecologic pathology; foreign body; infections; nutritional, metabolic, and immune abnormalities; abuse and neglect; and genitourinary issues, appendicitis, and even peptic ulcer disease. Whether you’re a physician-in-training, a pediatrician, a pediatric gastroenterologist, a surgeon, specialist, or clinician, you may not have the luxury to quickly refer to a center with specialists, subspecialists, and even sub-subspecialists, such as pediatric interventional endoscopists, which can impact referral decisions and take on a different degree of urgency, depending on the acuity of illness and available expertise. Boost your confidence in making an accurate GI testing, diagnosis, and treatment plan while mitigating risks involved in imaging or referrals that may cause significant further expense.