This edited collection unravels the intricate dynamics of tourism and hospitality, offering evidence-based strategies to address global challenges. Part of a two-volume work, this first volume navigates the evolving nexus, emphasizing the critical importance of sustainability, resilience, agility, and adaptability in the face of economic, geopolitical, environmental, and other disruptions. Venturing beyond traditional paradigms, the book explores the multifaceted issues impacting the tourism and hospitality industries, presenting theoretical and practical solutions at both organizational and societal levels.  Chapters focus on the strategic redesign of philosophy and practice in response to crises, highlighting the need for tactically flexible approaches to build resilience and agility within the industry. Utilizing empirical scientific methodologies and international literature analyses, the volume draws evidence from diverse organizational typologies and geographic sectors, addressing significant business factors such as human resource management, quality management, and technology.  Amidst challenges and transformative changes, the book advocates for a balanced well-being approach, recognizing the experiential and dynamic nature of tourism and hospitality. It explores how personalized, authentic experiences can preserve local resources, cultures, and environments, while addressing the sharing economy's disruptive impact on traditional business models. It presents cross-disciplinary contributions that offer multi-perspective insights  and is  essential for scholars, practitioners, and policymakers seeking to enhance competitiveness and resilience in global tourism and hospitality.