Malaria is a vector-borne disease shaped by parasite biology, mosquito ecology, and human behavior. This handbook synthesizes parasite lifecycles, diagnostic approaches (microscopy, RDTs, PCR), antimalarial pharmacology, and case management algorithms for uncomplicated and severe malaria. Prevention chapters explore vector control (LLINs, IRS), environmental management, and emerging issues like insecticide and drug resistance. Surveillance, elimination strategies, and modelling tools for targeting interventions are illustrated with regional program experiences. The book also addresses malaria in pregnancy, co-infections, and operational challenges in low-resource settings. Useful for clinicians, entomologists, public-health officers, and elimination strategists.