This handbook provides the latest research related to quality of life and sustainability, taking into account social, economic, environmental, and political/governance aspects as well as specific socio-spatial contexts. The volume includes contributions from established and upcoming scholars from various disciplines and geographical contexts (Global South and North). The varying cultural and socio-spatial contexts of the authors in the selected cases contribute to first-hand knowledge on the realities of sustainability issues affecting the quality of life. The authors apply a wide diversity of methods and tools, which facilitates a unique understanding of the interlinkages between quality of life and sustainability. The chapters are grouped in three main sections: concepts and foundations; tools, techniques, and applications; and innovations. The authors provide their own view and theoretical approximation of the dimensions of sustainability, in particular on how these dimensions play out in relation to quality of life. The combination of sustainability and quality of life concepts and perspectives is particularly important in unravelling the multi-faceted nature of human, urban, rural/spatial development.