From foremost authorities, this needed work demonstrates the importance of a science of literacy perspective for teaching and learning beyond the primary grades. Contributors present cutting-edge research on reading and writing development in grades 3–8 and review evidence-based classroom practices and professional learning frameworks. The Handbook explores how to support upper elementary and middle grades learners in improving morphological knowledge and vocabulary, understanding text complexity, and building comprehension. It describes effective ways to meet the instructional needs of struggling readers and writers, including multilingual students and those with learning disabilities. Timely topics include multi-tiered systems of support, student motivation and engagement, adaptive teaching, digital and multimodal literacies, and culturally responsive and sustaining practices.