This new and thoroughly updated textbook set elucidates the etiology of heart failure (HF) to assist understanding of the clinical therapies and surgery available.  It explains these in light of the better understanding of the pathophysiology of HF, which has translated into dramatic improvements in patient outcome.  The chapters detail the causes, diagnosis and treatment of HF, recognizing that having become the leading cause of morbidity, mortality and hospitalization in the developed world, even patients with the most advanced HF have options that allow prolonged survival. This includes alternatives to cardiac transplantation, including mechanical circulatory support with a rapidly growing number of new, smaller, more reliable devices becoming available.  Heart Failure: A Comprehensive Guide to Pathophysiology and Clinical Care remains an important reference for all involved in the management of these patients and provides a scientific and clinical resource for trainees in cardiovascular disease as well as physicians involved in caring for these patients.