In this issue of Cardiology Clinics, guest editor Dr. Asad Ghafoor brings his considerable expertise to the topic of Heart Failure with Reduced Ejection Fraction. Top experts in the field cover issues such as choosing temporary mechanical support in cardiogenic shock; sequencing in quadruple therapy for HFrEF; the war against heart failure hospitalizations: remote monitoring and the case for expanding criteria; the uncertain benefit from ICDs in nonischemic cardiomyopathy; frailty and its spectrum of implications in HFrEF; and more.

• Contains 12 relevant, practice-oriented topics including HFrEF and COVID-19: unmasking health inequities during a pandemic; our goals for prevention versus treating HFrEF with modern tech; the economic burden of HFrEF: living longer but poorer?; obesity in heart failure; the value of cardiopulmonary exercise testing in ambulatory HFrEF; and more.
• Provides in-depth clinical reviews on heart failure with reduced ejection fraction, offering actionable insights for clinical practice.
• Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.