A recent upsurge of research examining inositol phospholipids (IP)—membrane-bound species fundamental to cell signaling—continues underscore the role of this pathway in both normal and disease-associated cellular physiology.  This volume includes a selection of cutting-edge, multidisciplinary reports borne out of the conference “Inositol Phospholipid Signaling in Physiology and Disease” held June 26–27, 2012 at the New York Academy of Sciences in New York City.  Papers include important developments investigating IP signaling in immunology, cancer, inflammation, and metabolic disorders. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.