This edited volume strives to support leaders in successfully leading their teams, projects and organizations across borders in an increasingly boundaryless world. From both an academic’s and a practitioner’s perspective, the book focuses on international leaders and their potential to be or become enablers of international success, for and within their respective organizations. The authors are a curated selection of established experts, seasoned leaders, and new voices showcasing novel research, best practices, and business cases. The contributions are assigned to three sections, corresponding to the three core challenges of international leadership: Leading international organizations, leading international teams, and (self)leadership with intercultural excellence. An additional section is dedicated to case studies, exhibiting these challenges in practice. The Foundation of the Swiss Society for Organization and Management (SGO) as well as Innosuisse – Swiss Innovation Agency supported the creation of this book.