This book constitutes the thoroughly refereedpost-conference proceedings of the 10th International Conference on Large-ScaleScientific Computations, LSSC 2015, held in Sozopol, Bulgaria, in June 2015.

The 49 revised full papers presented were carefullyreviewed and selected from 64 submissions. The general theme for LSSC 2015 wasLarge-Scale Scientific Computing with a particular focus on the organizedspecial sessions: enabling exascale computation; control and uncertain systems;computational microelectronics - from monte carlo to deterministic approaches;numerical methods for multiphysics problems; large-scale models: numericalmethods, parallel computations and applications; mathematical modeling andanalysis of PDEs describing physical problems; a posteriori error control anditerative methods for maxwell type problems; efficient algorithms for hybridHPC systems; multilevel methods on graphs; and applications of metaheuristicsto large-scale problems.