**American Journal of Nursing (AJN) Book of the Year Awards, 2nd Place in Advanced Practice Nursing, 2025****Selected for 2026 Doody's Core Titles as an Essential Purchase in Advanced Practice**Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants, Third Edition builds on the same foundation of clearly explained, up-to-date, and clinically current content as Lehne’s trusted undergraduate text, while focusing on the information that advanced practice nurses and Physician Assistants specifically need for safe and effective prescribing. Introductory chapters provide foundational content in the areas of prescriptive authority, rational drug selection, prescription writing, and promoting positive outcomes of drug therapy. Core drug chapters focus on the drugs that you will most commonly see in clinical practice. Pharmacotherapeutic decision-making is emphasized, with Black Box Warnings and new Drug Decision Guide boxes. This edition features completely updated content with new chapters on drugs for sexual dysfunction and drugs for transgender health. It’s everything you need to be a safe and effective prescriber!UPDATED! Content throughout reflects the latest drug information and evidence-based treatment guidelines and protocolsNEW! Drugs for Sexual Dysfunction and Drugs for Transgender Health chapters in a newly combined Reproductive Health unit promote health equityNEW! Drug Decision Guide boxes for selected drugs emphasize a rational process for drug selectionNEW! Clinical Pearls boxes highlight expert tips for rational drug prescriptionNEW! Chapter-opening Evolve links and “Top 300” drug icons throughout identify drugs that appear on the Top 300 prescribed drug list to help you focus your study timeENHANCED! Introductory chapters emphasize prescriber-level pharmacokinetics and pharmacodynamics contentNEW! Coverage addresses immunizations and therapeutics (e.g., Regeneron, Resdemivir, dexamethasone) for SARS-CoV-2 infection (COVID-19)UPDATED! Enhanced coverage of sexually transmitted infections reflects the latest evidence-based guidelinesNEW! Drug content addresses medications for ectoparasite infestationsIntroductory chapters tailored to the specific needs of beginning prescribers cover topics such as prescriptive authority, rational drug selection and prescription writing, and promoting positive outcomes of drug therapyCarefully focused pharmacotherapeutics content reflects the drugs most commonly seen and used by primary and acute care prescribers, with an emphasis not on the first drug discovered or developed in each drug class, but on the agents most often used todayChapters address primary care drugs first, as appropriate, followed by acute care drugsPrescriber-focused pedagogical aids further reinforce the most important information for prescribersUNIQUE! Summary of Key Prescribing Considerations at the end of each drug chapter provides a concise summary of essential prescriber informationCoverage of interprofessional collaboration addresses the growing global emphasis on interprofessional collaboration and incorporates opportunities for interprofessional collaborative practice throughoutIntegrated coverage of Canadian trade names appears throughout and is highlighted with a familiar maple-leaf icon