This book advances a new interdisciplinary approach that engages with the concepts of science and literature through the mediation of philosophy (with a focus on the ideas of Gilbert Simondon and Gilles Deleuze). It investigates in innovative ways the multifaceted dimensions of creation, of genesis, considered here in artistic and mathematical terms as “heterogenesis”. The dialogic interaction among the three domains generates a renewed analysis of poems selected in the work of particularly inventive poets, both French and American—Emily Dickinson, e.e. cummings and Francis Ponge—as well as the artwork of Pierre Soulages, Anna-Eva Bergman and Cy Twombly. Literary Heterogenesis. Diagrammatic Dynamics. The Interplay of the Virtual and the Actual will interest specialists of mathematics, physics, literary theory and criticism, philosophy, and epistemology. It will also attract any curious mind drawn to the bridging of disciplines and the concepts of the two cultures.