This book provides a comprehensive and up-to-date overview of wound healing, from its biological foundations to the most advanced therapeutic frontiers. Written by internationally recognized experts, it covers the history, anatomy, histology, and pathophysiology of wound repair, alongside clinical assessment tools and evidence-based multidisciplinary strategies for hard-to-heal wounds. The chapters explore cellular and molecular mechanisms, the role of growth factors, cytokines, and the immune system, as well as preclinical models and translational approaches. A significant focus is given to innovative regenerative strategies, including the use of extracellular vesicles, stem cells, adipose-derived stem cells, and bone marrow-derived cells, alongside novel biomaterials, skin substitutes, and advanced wound dressings. Specialized sections address chronic wounds, diabetic foot ulcers, burns, and scar management, as well as emerging topics like bioengineering, nanotechnology, AI, and personalized medicine in wound care. This volume aims to equip practitioners, researchers, and students with the scientific knowledge and practical insights needed to select and apply strategies that optimize functional and aesthetic outcomes, reduce complications, and accelerate healing through safe, cutting-edge, and minimally invasive approaches.