In this issue of Gastroenterology Clinics, guest editors Dr. Colleen R. Kelly brings her considerable expertise to the topic of Mastering Clostridioides difficile Infection: Comprehensive Insights and Patient-Focused Care. Increasing rates of C. difficile infection, specifically community-acquired and multiply recurrent infections, have occurred over the past 20 years. In the era of nucleic acid amplification-based testing, diagnostic challenges have become apparent, and making an accurate diagnosis is important given newer therapeutic options for treatment and prevention of recurrence. This issue provides the most current information on management of C. difficile infection with the goal of improving patient outcomes. Contains 11 relevant, practice-oriented topics, including understanding the pathophysiology of C. difficile infection, colonization, and making an accurate diagnosis; management of C. difficile infection in patients with IBD; fecal microbiota transplantation for recurrent C. difficile infection; FDA-approved fecal microbiota-based therapies for C. difficile infection; the patient's perspective on experiencing C. difficile infection and impact on quality of life; and more. Provides in-depth clinical reviews on mastering Clostridioides difficile infection: comprehensive insights and patient-focused care, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.