Clinicians and caregivers face high risks of burnout, stress, and emotional fatigue from the demands of giving care to those in need over time. Mindfulness-based interventions can promote self-care and reduce caregiver burden. Mindful Self-Care for Clinicians and Caregivers (MSCC) offers participants the opportunity to access the privileges of caregiving and to enhance resilience and well-being. This practical, evidence-based guide supports facilitators of groups focused on Mindful Self-Care for Clinicians and Caregivers . This guide is developed by experienced mental health professionals and scholars, and offers the following key features:Step-by-step session guides for in-person and virtual delivery of MSCCDownloadable resources: participant handouts, audio meditations, videos, and visual aidsFacilitation tips and strategies for common challengesCultural considerations and adaptable group structuresTheoretical and empirical foundations including hypotheses and methods for researchers and studentsFlexible use for group facilitation or individual self-studyThe guide also explores the emotional demands of caregiving and offers models to understand and promote Mindful Self-Care for Clinicians and Caregivers. An online companion site provides multimedia support for facilitators. Whether used in clinical settings, in educating practitioners, or for personal growth, this guide promotes sustainable, compassionate caregiving and self-care through learning the fundamental skills of mindful practice.