This proceedings volume highlights a selection of papers presented at the 7th International Conference on High Performance Scientific Computing, which took place in Hanoi, Vietnam, during March 19-23, 2018. The conference has been organized by the Institute of Mathematics of the Vietnam Academy of Science and Technology, the Interdisciplinary Center for Scientific Computing (IWR) of Heidelberg University and the Vietnam Institute for Advanced Study in Mathematics. The contributions cover a broad, interdisciplinary spectrum of scientific computing and showcase recent advances in theory, methods, and practical applications. Subjects covered include numerical simulation, methods for optimization and control, machine learning, parallel computing and software development, as well as the applications of scientific computing in mechanical engineering, airspace engineering, environmental physics, decision making, hydrogeology, material science and electric circuits.