Based on the social media success of my series of articles around ‘The Rules of Radiology’ this follows on from the first volume (‘The Rules of Radiology’), published in 2021. ‘More Rules of Radiology’ is the second and final volume that contains Rules 51-100. The Rules provide a guide to what radiology is and what radiologists do. Or rather what radiology should be and what radiologists should do. This book and its prior sister volume looks hard not just at radiology but also provides a distinctly wry look at the curious and occasionally alien world of hospital-based medical practice. I ask questions and poke fun but it is serious intent. My motto is ‘first make you laugh, then make you think’. Or, as George Bernard Shaw wrote, “My method is to take the utmost trouble to find the right thing to say, and then to say it with the utmost levity”. Each of the Rules addresses an important part of professional practice. I analyse the underpinning concepts of modern radiology, critically reflect on underlying assumptions, pose thoughtful questions and provide measured debate. All sprinkled with a mixture of weak jokes, puns and gratuitous word play. As a relatively young but rapidly expanding specialty, there has been no guide for radiologists, no moral compass. Until now. I provide opinions and guidance on key matters; sometimes controversial but always reasoned. The hope is to provide the reader with much food for thought. Not only that but this volume and its predecessor aim to provide a manifesto for radiologists across the globe to raise their game and serve their patients better.