This Annals volume presents a series of short reviews stemming from the 2012 3rd International Conference on Nutrition and Physical Activity (NAPA) in Aging, Obesity, and Cancer.  The papers focus on advances in, and future directions for, physical and nutritional bio-modulation and prevention of aging, obesity, and cancer. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632p> ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (ww.nyas.org). Members of the New York Academy of Sciences received full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.