This book gathers cutting-edge research and best practices relating to occupational risk and safetymanagement, healthcare, and ergonomics. It covers strategies for different industries, such as construction,chemical, and healthcare. It emphasizes challenges posed by automation, discusses solutions offered bytechnologies, and reports on case studies carried out in different countries. Chapters are based on selectedcontributions to the 21st International Symposium on Occupational Safety and Hygiene (SHO 2024), held onJuly 4-5, 2024, in Porto, Portugal. By reporting on different perspectives, such as the ones from managers,employees, and OSH professionals, and covering timely issues, such as implications of telework, issues relatedto gender inequality and applications of machine learning techniques in occupational health, this book offersextensive information and a source of inspiration to OSH researchers, practitioners, and organizationsoperating in both local and global contexts. This is the first volume of a 2-volume set.